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The levonorgestrel (a progestin) protects against the risk of cancer in the uterus caused by estrogen treatment.
Similar to the WHI trial that used the combination of estrogen and progestogen, the estrogen-only WHI trial showed an increase in strokes and a small increase in the risk of VTE.
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There does not appear to be an increased risk of stroke in women who begin hormone therapy between 50 and 59 years of age, although information is inconsistent.
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Hot flashes were present in 5 subjects during placebo therapy and were reported by 2 subjects during estradiol therapy.
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Mild hirsutism, edema, hair loss, voice change, which may take the form of hoarseness, sore throat or of instability or deepening of pitch, may occur and may persist after cessation of therapy.
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Estradiol (an estrogen) reduces hot flashes and night sweats and prevents bone loss, but can also harm cells in the uterus after menopause.
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